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Topical Liposomal Gel Of Tretinoin For The Treatment Of Acne
By A J Jackson

Summary of research:

An attempt was made to pharmaceutically develop a topical liposomal tretinoin ( TRE ) gel and clinically evaluate the developed formulation for the treatment of in patients. Liposomes of TRE were prepared using the lipid film hydration technique and the entrapment efficiency of TRE in liposomes was optimized to 79. 96 %. The drug retention in liposomes and in liposomal TRE gel ( Carbopol 934 gel base ) studied at three storage conditions indicated maximum drug retention at refrigeration temperature. For liposomal TRE gel, reduced drug leakage was observed as compared to that of liposomes at all three storage conditions. Diffusion studies of plain TRE gel and liposomal TRE gel suggested perpetuation ( 3. 4 times reduction in flux value ) of drug diffusion and halfway two - fold increase in

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skin drug retention after liposomal encapsulation of drug. A comparative double - blind clinical study of the developed liposomal TRE gel, carried out on 30 patients over a period of 3 months, demonstrated significant enhancement ( about 1. 5 - fold ) in drug efficacy. More remarkable improvement was observed in the treatment of comedones, where the mean percent reduction in lesions increased from 62. 36 % for plain TRE gel to 94. 17 % for liposomal TRE gel. Erythema and cat fit associated with the use of casual TRE gel was reduced absolutely with the use of liposomal TRE gel. The findings of this investigation therefore underscore potential utility of commercialization of liposomal TRE gel in the treatment of Acne.

Report Title: Topical liposomal gel of tretinoin for the treatment of Acne: research and clinical implications.
Researcher ( s ): Patel VB, Misra A, Marfatia YS
From Journal: Pharm Dev Technol, 5 ( 4 ): 455 - 64 2000

To earn the full report, please visit PurpleHealth Medical Research Service
Adam Jackson is a medical writer / researcher specialising in effective, natural solutions to common health problems. He is a qualified Matching medical practitioner and a former columnist for the Nursing Times & Editor of http://www.internethealthlibrary.com . He has written seven books which have been published around the world & translated into 27 languages. He has a reserved interest in skin care.

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	Photodynamic Therapy Combined With Topical Therapy For Mild To Severe Acne By A J Jackson Summary of test: Acne patients who fail to respond to conventional treatments obtain been treated with isotretinoin, an effective treatment coming under strict regulation due Read more...
	Photodynamic Therapy Combined With Topical Therapy For Mild To Severe Acne By A J Jackson Summary of test: Acne patients who fail to respond to conventional treatments obtain been treated with isotretinoin, an effective treatment coming under strict regulation due Read more...

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