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Vitamin E Does Not Reduce The Side - effects Of Isotretinoin In The Treatment Of Acne Vulgaris
By A J Jackson

Summary of research:

Isotretinoin is widely used in the treatment of severe, recalcitrant, nodular Acne. Mucocutaneous side - effects are seen in the great majority of patients and some of them have elevations in their serum lipid and liver enzyme profiles. Recently, it has been shown that addition of vitamin E decreased the toxicity of high - dose retinoids. OBJECTIVE: The purpose of this investigator - blinded, randomized study was to assess whether vitamin E would reduce the side - effects of isotretinoin in the treatment of vulgaris.

The researchers methods: Eighty two patients were randomly assigned to one of two treatment groups with isotretinoin ( 1 mg / kg / day ) alone

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or combined with vitamin E ( 800 IU / day ). The treatment duration was 16 weeks. Mucocutaneous side - effects such as facial erythema, facial dryness, cheilitis and serum lipid and liver enzyme profiles were assessed.

The outcome of this Research: There was no difference in the incidence and severity of side - effects related to isotretinoin between the two treatment groups.

The report's conclusion: Eight hundred IU / day vitamin E did not improve the side - effects of 1 mg / kg / day of isotretinoin in the treatment of vulgaris.

Report Title: Vitamin E does not reduce the side - effects of isotretinoin in the treatment of vulgaris.
Researcher ( s ): Kus S, Gün D, Demirçay Z, Sur H
From Journal: Int J Dermatol, 44 ( 3 ): 248 - 51 2005

To obtain the full report, please visit PurpleHealth Medical Research Service
Adam Jackson is a medical writer / researcher specialising in effective, natural solutions to common health problems. He is a qualified Complementary medical practitioner and a former columnist for the Nursing Times & Editor of http://www.internethealthlibrary.com . He has written seven books which have been published around the world & translated into 27 languages. He has a special interest in skin care.

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