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Concomitant Administration Of Vitamin E Does Not Change The Side Effects Of Isotretinoin As Used In Acne Vulgaris
By A J Jackson

Summary of research:

Isotretinoin treatment is frequently associated with reversible, dose - related side effects. Recent studies claimed that combining vitamin E with high - dose isotretinoin ameliorated isotretinoin - induced side effects.

OBJECTIVE: The purpose of this double - blind, randomized study was to determine the effects of a fixed dose of vitamin E on the side effects of isotretinoin for treatment - resistant vulgaris.

The researchers methods: One hundred forty subjects were randomly assigned to one of two treatment programs with isotretinoin ( 1 mg / kg ) together with either vitamin E ( 800 IU / day ) or a vitamin E placebo for 20 weeks. The incidence, severity,

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and duration of the side effects ( eg, dry eyes, dry lips ) were assessed.

The outcome of this Research: A fixed 800 IU / day dose of vitamin E did not improve the incidence, severity, or duration of side effects associated with isotretinoin ( 1 mg / kg per day ).

The report's conclusion: Vitamin E did not significantly ameliorate retinoid side effects when combined with 1 mg / kg of isotretinoin in the treatment of Acne.

Report Title: Concomitant administration of vitamin E does not change the side effects of isotretinoin as used in vulgaris: a randomized trial.
Researcher ( s ): Strauss JS, Gottlieb AB, Jones T, Koo JY, Leyden JJ, Lucky A, Pappas AA, McLane J, Leach EE
From Journal: J Am Acad Dermatol, 43 ( 5 Pt 1 ): 777 - 84 2000

To obtain the full report, please visit PurpleHealth Medical Research Service
Adam Jackson is a medical writer / researcher specialising in effective, natural solutions to common health problems. He is a qualified Complementary medical practitioner and a former columnist for the Nursing Times & Editor of http://www.internethealthlibrary.com . He has written seven books which have been published around the world & translated into 27 languages. He has a special interest in skin care.

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	Overview Of The Evaluation And Management Of Acne Vulgaris By A J Jackson Summary of research: Acne vulgaris is a disease of the pilosebaceous unit where abnormally adherent keratinocytes cause plugging of the follicular duct followed by accumulation Read more...

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