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Concomitant Administration Of Vitamin E Does Not Change The Side Effects Of Isotretinoin As Used In Acne Vulgaris
By A J Jackson


Summary of research:

Isotretinoin treatment is frequently associated with reversible, dose - related side effects. Recent studies claimed that combining vitamin E with high - dose isotretinoin ameliorated isotretinoin - induced side effects.

OBJECTIVE: The purpose of this double - blind, randomized study was to determine the effects of a fixed dose of vitamin E on the side effects of isotretinoin for treatment - resistant vulgaris.

The researchers methods: One hundred forty subjects were randomly assigned to one of two treatment programs with isotretinoin ( 1 mg / kg ) together with either vitamin E ( 800 IU / day ) or a vitamin E placebo for 20 weeks. The incidence, severity,



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and duration of the side effects ( eg, dry eyes, dry lips ) were assessed.

The outcome of this Research: A fixed 800 IU / day dose of vitamin E did not improve the incidence, severity, or duration of side effects associated with isotretinoin ( 1 mg / kg per day ).

The report's conclusion: Vitamin E did not significantly ameliorate retinoid side effects when combined with 1 mg / kg of isotretinoin in the treatment of Acne.

Report Title: Concomitant administration of vitamin E does not change the side effects of isotretinoin as used in vulgaris: a randomized trial.
Researcher ( s ): Strauss JS, Gottlieb AB, Jones T, Koo JY, Leyden JJ, Lucky A, Pappas AA, McLane J, Leach EE
From Journal: J Am Acad Dermatol, 43 ( 5 Pt 1 ): 777 - 84 2000

To obtain the full report, please visit PurpleHealth Medical Research Service
Adam Jackson is a medical writer / researcher specialising in effective, natural solutions to common health problems. He is a qualified Complementary medical practitioner and a former columnist for the Nursing Times & Editor of http://www.internethealthlibrary.com . He has written seven books which have been published around the world & translated into 27 languages. He has a special interest in skin care.

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We scour the international medical databases to obtain only reliable, fully referenced articles & research papers on Acne Treatments.

If there is a specific topic related to Acne Treatments that you would like us to cover, please feel free to contact us at any time.

Led Phototherapy In The Treatment Of Mild To Severe Acne Vulgaris
By A J Jackson
Summary of research: BACKGROUND AND OBJECTIVE: Acne vulgaris represents both a challenge to the treating dermatologist and a major concern for the patient. Conventional Read more...

Overview Of The Evaluation And Management Of Acne Vulgaris
By A J Jackson
Summary of research: Acne vulgaris is a disease of the pilosebaceous unit where abnormally adherent keratinocytes cause plugging of the follicular duct followed by accumulation Read more...


 
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Topical Vitamin A Acid In The Treatment Of Acne Vulgaris
By A J Jackson
Summary of research: A controlled non - blind multicenter trial was conducted in 211 Acne patients to test the activity of topical retinoic acid against sulfur - resorcinol - - Read more...








The Role Of Pulsed Light And Heat Energy In Acne Clearance
By A J Jackson
Summary of research: Propionibacterium Acnes synthesize and store a large appraisal of porphyrins. Once the porphyrin is exposed to outermost light live becomes chemically Read more...
Anti - Acne Effects Of Oriental Herb Extracts
By A J Jackson
Summary of research: The Acne - therapeutic effects of Oriental herb extracts were investigated in terms of antichemotactic effect on polymorphonuclear leucocytes, Read more...
Efficacy And Safety Of Stabilised Hydrogen Peroxide Cream For Acne
By A J Jackson
Summary of research: Benzoyl peroxide ( BP ) is a first - line topical treatment in Acne vulgaris ( AV ). However, its use can cause mild skin irritation and dryness. A new Read more...

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