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Photodynamic Therapy Combined With Topical Therapy For Mild To Severe Acne
By A J Jackson
Summary of test:
Acne patients who fail to respond to conventional treatments obtain been treated with isotretinoin, an effective treatment coming under strict regulation due to the venture of cogent side effects. Photodynamic therapy ( PDT ) may produce a applicable alternative treatment for recalcitrant of various types and levels of severity. OBJECTIVE: To impel the safety and efficacy of combination PDT with topical 5 - aminolevulinic acid ( ALA ) and activation by long - pulsed, pulsed dye laser ( LP PDL, 595 nm ) energy with topical therapy in patients with mild to severe Acne.
The researchers methods: A prospective, controlled pilot, proof - of - principle study of 19 consecutive patients ( aged 16 - 47 years, Fitzpatrick skin types I - VI ) with mild to severe cystic, inflammatory, or comedonal of the face was conducted. All patients had failed conventional therapy, including oral antibiotics, topical treatments, hormonal therapy, laser procedures ( without ALA ), and / or oral isotretinoin. Fifteen patients were treated with ALA PDT and 4 patients served as controls; all were continued on topical medications. Patients undergoing PDT were initially randomized to make either blue light or laser energy. Because recrudescence occurred in 1 patient while undergoing mixed treatments with ALA and blue light, all subsequent patients were treated with ALA and laser energy. The total number of patients treated with LP PDL - mediated ALA PDT was 14. ALA was practical for a short 45 - minute incubation followed by 1 minimally overlapping pass with the LP PDL ( 595 nm, 7. 0 - 7. 5 J / cm2 fluence, 10 - ms beat lastingness, 10 - mm spot size, and dynamic cooling spray of 30 ms with a 30 - ms oscillate ). Patients treated with conventional therapy ( oral antibiotics,
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oral contraceptives, and topical medications ) or laser energy without ALA PDT served as control groups. Patients were followed monthly for enlargement to 13 months.
The preference of this Research: Complete clearance was achieved in 100 % ( 14 out of 14 ) patients in the LP PDL PDT - treated group. A mean of 2. 9 treatments ( range 1 - 6; 2. 0 - 3. 7, 95 % CI; n=14 ) was required to achieve thorough clearance for a miserly follow - up time of 6. 4 months ( range 1 - 13; 3. 8 - 8. 9 95 % CI; n=14 ). The patient mean percent lesional clearance scale per treatment was 77 % ( 64 % - 90 %, 95 % CI; n=14 ). Improvement in lesions became apparent within 1 to 2 weeks after the first treatment. Clearance in the LP PDL PDT group was superior to control groups. In the LP PDL - only control pack ( n=2 ), the patient mean percent lesional clearance degree per treatment was 32 % unredeemed complete clearance beside 3 to 4 treatments. In the oral antibiotics, oral contraceptives, and topicals supervision lot ( n=2 ), the clearance rate per treatment was 20 %, the mean clearance rate per month was 4 %, and complete clearance was not achieved after 6 to 10 months. In the LP PDL - mediated PDT group, treatments were well - tolerated with minimal erythema lifelong 1 to 2 days. No cases of crusting, blistering, purpura, scarring, or dyspigmentation occurred. A reduction in the erythema in erythematous scars was observed.
The report's conclusion: For teenage to adult patients with intractable comedonal, inflammatory, or cystic of unequal degrees of severity, ALA PDT with activation by LP PDL appears to typify a safe and effective treatment with minimal side effects. LP PDL - mediated PDT may serve as an important alternative to isotretinoin. Cosmetically well - accepted, LP PDL PDT combined with topical therapy is the first PDT modality to achieve complete clearance with long - term result - up as compared to controls.
Report Title: Long - pulsed dye laser - mediated photodynamic therapy combined with topical therapy for mild to severe comedonal, inflammatory, or cystic Acne.
Researcher ( s ): Alexiades - Armenakas M
From Journal: J Drugs Dermatol, 5 ( 1 ): 45 - 55 2006
To obtain the humungous report, please visitPurpleHealth Medical Research Service
Adam Jackson is a medical writer / researcher specialising in effective, natural solutions to common health problems. He is a vet Complementary medical practitioner and a former columnist for the Nursing Times & Editor of http://www.internethealthlibrary.com . He has written seven books which have been conscious around the world & translated into 27 languages. He has a special interest in skin care.
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