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Acne spots - Acne
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Efficacy And Safety Of Stabilised Hydrogen Peroxide Cream For Acne
By A J Jackson
Summary of research:
Benzoyl peroxide ( BP ) is a first - line topical treatment in vulgaris ( AV ). However, its use can cause mild skin irritation and dryness. A new formulation of hydrogen peroxide stabilised ( HPS ) in monoglycerides cream ( Crystacide 1 % ), indicated in the topical treatment of superficial skin infections, is now available as an alternative treatment. STUDY AIM: To evaluate efficacy and local tolerability of HPS in mild - to - moderate AV in comparison with BP gel. METHODS AND PATIENTS: In a randomised, prospective, investigator - masked parallel - group, 8 - present trial, 60 patients ( 24 men, 36 women, mean age 25 + / - 6 years ) with mild - to - moderate AV, affecting mainly the face, were enrolled in the study, after their informed pass on. HPS or BP ( PanOxyl gel 4 % ) was applied topically twice daily for 8 weeks. STUDY OUTCOMES: The study endpoints were: ( 1 ) Decrease in mean inflammatory ( IL ), noninflammatory ( NIL ) and total ( TL ) Acneic lesions in comparison with baseline; ( 2 ) Local tolerability assessed evaluating erythema, dryness and burning sensation, using a 0 - 3 qualitative score ( score 0 = flat broke tolerability; see through 3 = very good tolerability ).
The adjustment of this Research: TL, NIL, and IL were assessed by an investigator
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innocent of treatment allocation at baseline, and week 8. The tolerability score ( TS ) was assessed at week 4 and 8. At baseline, the two groups were well matched for the main clinical and demographic characteristics. All patients concluded the trial. At week 0, in the HPS cluster TL, NIL and IL ( mean + / - SD ) were: 35 + / - 8, 20 + / - 6 and 16 + / - 7. At week 8, HPS reduced TL to 16 + / - 7; Aught to 9 + / - 3 and IL to 7 + / - 3 ( p < 0. 001 ). At baseline, TL, NIL and IL, in the BP group, were 32 + / - 9, 24 + / - 8 and 18 + / - 7, respectively. At week 8, BP truly needy TL, NIL and IL to 14 + / - 9; 7 + / - 5 and 7 + / - 3 ( p < 0. 001 ). In comparison with baseline values, the percentage reductions of IL were 58 % and 61 % for HPS and BP, respectively ( p = n. s. ). At the end of the study the TS was 2. 9 + / - 0. 2 in HPS group and 2. 4 + / - 0. 8 in BP group ( p < 0. 025 ). Two patients in HPS group ( 6 % ) and seven patients ( 23 % ) in BP group suffered from mild - to - moderate local erythema.
The Report's Conclusions: HPS has shown to be as effective as BP in reducing both inflammatory and noninflammatory AV lesions in patients with mild - to - moderate disease. In comparison with BP 4 % gel, HPS cream shows a better local tolerability profile.
Report Title: Efficacy and safety of stabilised hydrogen peroxide cream ( Crystacide ) in mild - to - moderate vulgaris: a randomised, controlled trial versus benzoyl peroxide gel.
Researcher ( s ): Milani M, Bigardi A, Zavattarelli M
From Journal: Curr Med Res Opin, 19 ( 2 ): 135 - 8 2003
To obtain the full report, please visit PurpleHealth Medical Research Service
Adam Jackson is a medical writer / researcher specialising in effective, natural solutions to common health problems. He is a qualified Complementary medical practitioner and a former columnist for the Nursing Times & Editor of http://www.internethealthlibrary.com . He has written seven books which have been published around the sphere & translated into 27 languages. He has a special interest in skin care.
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