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Acne Therapy - A Methodologic Review
By A J Jackson


Summary of research:

Acne is a very common problem with significant physical and psychological morbidity. The evidence basis for its treatment had not been systematically reviewed. Hence, we performed an evidence review to provide researchers a basis for additional studies, and to provide clinicians the involvement needed to interpret current and future clinical studies. OBJECTIVE: The researchers restate the methodologic state of the literature in patients with who do not have complicating co - morbidities.

The researchers methods: This was an expert - advised literature synthesis. The researchers used a structured literature prospect for English - language controlled trials in Cochrane National, MEDLINE, OLDMEDLINE, HSTAT, CINAHL, and PsychInfo. Results underwent a structured data abstraction process, with review by at least 2 reviewers.

The outcome of this Examine: Out of 1588 unique articles, 250 articles ( 274 controlled trials ) over the past 50 years were reviewed: 57 ( 21 % ) trials had at least one major weakness

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and no strengths; 125 ( 47 % ) trials had at anterior one major strength and at least one major weakness; 48 ( 18 % ) trials had at least one major strength, and no major weaknesses. The remaining 16 ( 6 % ) were of intermediate quality or did not provide enough information to accomplish a determination. One fourth of studies did not report perceptive age; peerless fourth did not report on patient gender. Only 8 % mentioned patient race; only 2 % mentioned skin ethos; 0. 4 % mentioned diet; none scored sexual maturity or insurance status. There were 1237 outcomes. There were more than 25 methods of assessing severity and more than 19 methods for counting lesions. There were only two trials that formally assessed psychological outcomes. More than 140 treatments were tested in 251 comparisons.

The report's impression: Ranging over 50 years of scrutinize, the literature evidences mungo heterogeneity at all levels: patient characteristics, severity, outcome assessments, treatments, and comparisons. A list of methodologic recommendations is provided.

Report Title: Acne therapy: a methodologic review.
Researcher ( s ): Lehmann HP, Robinson KA, Andrews JS, Holloway V, Goodman SN
From Journal: J Am Acad Dermatol, 47 ( 2 ): 231 - 40 2002

To obtain the full report, please visit PurpleHealth Medical Research Service
Adam Jackson is a medical writer / researcher specialising in effective, natural solutions to common health problems. He is a qualified Complementary medical practitioner and a former columnist for the Nursing Times & Editor of http://www.internethealthlibrary.com . He has written seven books which have been published around the world & translated relaxation 27 languages. He has a special interest in skin care.

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