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Japanese Herbal Medicine Treatment For Acne By A J Jackson
Summary of research:
On the basis of recent reports that keigai - rengyo - to ( TJ - 50 ), an oral Japanese Kampo ( herb ) medicine, is clinically effective in treating Acne, and that tetracyclines are effective against by acting directly as an antioxidant on infiltrated neutrophils, we investigated the effect of TJ - 50 on the generation of reactive oxygen species ( ROS ), using human neutrophils and a cell - free, xanthine - xanthine oxidase system. The species investigated were superoxide radical anion ( O2 - ), hydrogen peroxide ( H2O2 ), and hydroxyl radical ( OH. ). In addition, neutrophil chemotaxis, phagocytosis and calcium concentration, [Ca2 + ]i in neutrophils were also
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assessed. TJ - 50 significantly decreased neutrophil - generated O2 -, H2O2 and OH. in a dose - dependent manner. Three kinds of ROS generated in the cell - free system were also reduced in the presence of TJ - 50. On the other hand, the medicine did not markedly affect neutrophil chemotaxis, phagocytosis or [Ca2 + ]i in neutrophils. The researchers' results indicate that the clinical effectiveness of TJ - 50 in the treatment of may be due partly to its antioxidant action on infiltrated neutrophils.
Report Title: Effect of keigai - rengyo - to, a Japanese kampo medicine, on neutrophil functions: a possible mechanism of action of keigai - rengyo - to in Acne.
Researcher ( s ): Akamatsu H, Asada Y, Horio T
From Journal: J Int Med Res, 25 ( 5 ): 255 - 65 1997
To obtain the full report, please visit PurpleHealth Medical Research Service Adam Jackson is a medical writer / researcher specialising in effective, natural solutions to common health problems. He is a qualified Complementary medical practitioner and a former columnist for the Nursing Times & Editor of http://www.internethealthlibrary.com . He has written seven books which have been published around the world & translated into 27 languages. He has a special interest in skin care.
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