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an inflammatory disease involving the sebaceous glands of the skin; characterized by papules or pustules or comedones

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Adrenal Function In Women With Idiopathic Acne
By A J Jackson

Summary of research:

The adrenal secretion of androgens were examined in 9 women ( ages 19 - 39 yr ) with postadolescent idiopathic and compared to age and sex - matched normal controls. Plasma dehydroepiandrosterone ( DHA ), dehydroepiandrosterone sulfate ( DHAS ), androstenedione ( delta 4 - delta ), cortisol, 17 - hydroxyprogesterone, 11 - deoxycortisol, and testosterone were measured by radioimmunoassay in the basal state and during a 48 hr ACTH infusion. The mean plasma and time - integrated plasma levels of the 3 adrenal androgens in patients with were 15 - 25 % higher than normal controls, but the groups were not significantly different ( p greater than. 05 ). The plasma testosterone values, on the other hand, were

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similar in both groups. In addition, cortisol, 11 - deoxycortisol and 17 - hydroxyprogesterone basal plasma values and responses to ACTH in patients with were similar to the normal control values. These findings suggest that adrenal androgen secretion is at most mildly elevated in patients with idiopathic and is unlikely to be the sole cause of since many patients without have similar hormone levels. Increased sensitivity of the sebaceous gland to androgens or increased local metabolism of androgen hormones in the skin to potent androgen metabolites may offer alternative mechanisms for the pathogenesis of this disorder.

Report Title: Adrenal function in women with idiopathic Acne.
Researcher ( s ): Chrousos GP, Peck GL, Gross EG, Cutler GB, Loriaux DL
From Journal: J Invest Dermatol, 78 ( 6 ): 468 - 71 1982

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Adam Jackson is a medical writer / researcher specialising in effective, natural solutions to common health problems. He is a qualified Complementary medical practitioner and a former columnist for the Nursing Times & Editor of http://www.internethealthlibrary.com . He has written seven books which have been published around the world & translated into 27 languages. He has a special interest in skin care.

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